Browsing Experimentally Confirmed database

Result: Your query found 77 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
cmtR
  • BacMet ID: BAC0071
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.
  • Length (amino acid): 118
  • Reference: Cavet et al. 2003; Pubmed- 12939264

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0203
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrA. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 1076
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0542
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2465
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0543
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2464
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0544
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2457
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0545
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2460
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0546
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2458
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrB
  • BacMet ID: BAC0204
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrB. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 395
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrC
  • BacMet ID: BAC0072
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrC; The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 418
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrH
  • BacMet ID: BAC0073
  • Code for: Regulator
  • Family: Sigma-70 factor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: RNA polymerase sigma factor CnrH; CnrH alone is able to activate cnr Expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.
  • Length (amino acid): 191
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrR/cnrX
  • BacMet ID: BAC0291
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance operon regulator CnrR. CnrH alone is able to activate cnr expression, while both CnrY and CnrR (CnrX) are needed for nickel induction of CnrH. Has been suggested to bind nickel.
  • Length (amino acid): 148
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463, Tibazarwa et al. 2000; Pubmed- 10671464

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrT
  • BacMet ID: BAC0074
  • Code for: Membrane Transporter
  • Family: EamA-like transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Cupriavidus metallidurans)
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: CnrT, Cation Diffusion Facilitator, involved in Co(II), Ni(II) resistance
  • Length (amino acid): 351
  • Reference: Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrY
  • BacMet ID: BAC0075
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Cupriavidus metallidurans)
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrY; CnrY and CnrX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift) or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.
  • Length (amino acid): 95
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    corA
  • BacMet ID: BAC0086
  • Code for: Membrane Transporter
  • Family: CorA metal ion transporter (MIT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)
  • Description: Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.
  • Length (amino acid): 316
  • Reference: Park et al. 1976; Pubmed- 780341

    		• Similar resistance genes in 'BacMet Predicted database'
    corA
  • BacMet ID: BAC0641
  • Code for: Membrane Transporter
  • Family: CorA metal ion transporter (MIT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)
  • Description: Mediates both influx and efflux of magnesium ions. Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.
  • Length (amino acid): 316
  • Reference: Smith et al. 1998; Pubmed- 9786860, Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpD
  • BacMet ID: BAC0099
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium smegmatis
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Probable cobalt/nickel-exporting P-type ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell.
  • Length (amino acid): 657
  • Reference: Raimunda et al. 2012; Pubmed- 22591178

    		• Similar resistance genes in 'BacMet Predicted database'
    cznA
  • BacMet ID: BAC0127
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznA
  • Length (amino acid): 1019
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznB
  • BacMet ID: BAC0128
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznB
  • Length (amino acid): 351
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznC
  • BacMet ID: BAC0129
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel outer membrane efflux protein cznC
  • Length (amino acid): 424
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeF
  • BacMet ID: BAC0132
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Wautersia metallidurans CH34
  • Location: Plasmid pMOL28 (Wautersia metallidurans CH34)
  • Compound: Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34.
  • Length (amino acid): 382
  • Reference: Scherer et al. 2009; Pubmed- 19602147, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeF
  • BacMet ID: BAC0482
  • Code for: Efflux
  • Family: Cation Diffusion Facilitator (CDF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions.
  • Length (amino acid): 323
  • Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeR
  • BacMet ID: BAC0475
  • Code for: Efflux
  • Family: Cation Diffusion Facilitator (CDF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions.
  • Length (amino acid): 90
  • Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501

    		• Similar resistance genes in 'BacMet Predicted database'
    fecD
  • BacMet ID: BAC0163
  • Code for: Enzyme
  • Family: Binding-protein-dependent transport system permease family. FecCD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Fe(3+) dicitrate transport system permease protein FecD; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 318
  • Reference: Stoof et al. 2010; Pubmed- 20643857

    		• Similar resistance genes in 'BacMet Predicted database'
    fecE
  • BacMet ID: BAC0164
  • Code for: Membrane Transporter
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for energy coupling to the transport system
  • Length (amino acid): 255
  • Reference: Stoof et al. 2010; Pubmed- 20643857

    		• Similar resistance genes in 'BacMet Predicted database'
    fieF/yiip
  • BacMet ID: BAC0167
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.
  • Length (amino acid): 300
  • Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    fptA
  • BacMet ID: BAC0168
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Iron (Fe), Cobalt (Co), Nickel (Ni), Gallium (Ga)
  • Description: Fe(3+)-pyochelin receptor FptA; High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin
  • Length (amino acid): 720
  • Reference: Braud et al. 2009; Pubmed- 19329644

    		• Similar resistance genes in 'BacMet Predicted database'
    fpvA
  • BacMet ID: BAC0169
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)
  • Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane
  • Length (amino acid): 815
  • Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567

    		• Similar resistance genes in 'BacMet Predicted database'
    hoxN
  • BacMet ID: BAC0191
  • Code for: Enzyme
  • Family: NiCo transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
  • Location: Plasmid megaplasmid pHG1 (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)),
  • Compound: Nickel (Ni)
  • Description: High-affinity nickel transporter hoxN responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease.
  • Length (amino acid): 351
  • Reference: Eitinger et al. 1991; Pubmed- 1847142, Wolfram et al. 1995; Pubmed- 7896709

    		• Similar resistance genes in 'BacMet Predicted database'
    hupE
  • BacMet ID: BAC0483
  • Code for: Enzyme
  • Family: HupE/UreJ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Plasmid pSym (Rhizobium leguminosarum bv. viciae)
  • Compound: Nickel (Ni)
  • Description: It is a metal permease. hupE gene, part of a highly conserved hup cluster and evolutionarily related to hydrogenase genes. It has a potential role as a nickel permease. It encodes a nickel transporter required for hydrogenase activity.
  • Length (amino acid): 191
  • Reference: Brito et al. 2010; Pubmed- 20023036

    		• Similar resistance genes in 'BacMet Predicted database'
    hupE2
  • BacMet ID: BAC0484
  • Code for: Enzyme
  • Family: HupE/UreJ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Plasmid pRLUPM791b (Rhizobium leguminosarum bv. viciae UPM791b)
  • Compound: Nickel (Ni)
  • Description: A hupE-homolog. It is a metal permease. There is a low level of amino acid sequence identity between hupE and hupE2. It is involved in hydrogen oxidation in R. leguminosarum bv. Viciae.
  • Length (amino acid): 199
  • Reference: Brito et al. 2010; Pubmed- 20023036

    		• Similar resistance genes in 'BacMet Predicted database'
    hupN
  • BacMet ID: BAC0193
  • Code for: Enzyme
  • Family: HupF/HypC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Azotobacter chroococcum mcd 1
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Hydrogenase nickel incorporation protein HupN
  • Length (amino acid): 108
  • Reference: Fu et al. 1994; Pubmed- 8197192

    		• Similar resistance genes in 'BacMet Predicted database'
    kmtR
  • BacMet ID: BAC0201
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: HTH-type transcriptional regulator KmtR; response to cobalt and nickel ions; Negatively auto-regulated
  • Length (amino acid): 130
  • Reference: Campbell et al. 2007; Pubmed- 17726022

    		• Similar resistance genes in 'BacMet Predicted database'
    mrdH
  • BacMet ID: BAC0254
  • Code for: Membrane Transporter
  • Family: NicO family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Membrane protein transpoeter mrdH
  • Length (amino acid): 377
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mreA
  • BacMet ID: BAC0255
  • Code for: Regulator
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Chromosome
  • Compound: Nickel (Ni), Zinc (Zn)
  • Description: Metal-sensitive repressor mreA, involved in resistance to metal ions. Bind nickel or zinc ions via conserved cysteine and histidine residues. In the absence of metal ions, this protein bind to promoter regions and repress transcription
  • Length (amino acid): 95
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mymT
  • BacMet ID: BAC0262
  • Code for: Binding protein
  • Family: Metallothionein superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu), Nickel (Ni), Zinc (Zn)
  • Description: Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese.
  • Length (amino acid): 53
  • Reference: Gold et al. 2011; Pubmed- 18724363, Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    nccA
  • BacMet ID: BAC0549
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.
  • Length (amino acid): 1076
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccB
  • BacMet ID: BAC0550
  • Code for: Efflux
  • Family: RND superfamily, Membrane Fusion Protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 397
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccC
  • BacMet ID: BAC0551
  • Code for: Efflux
  • Family: RND superfamily, Outer Membrane factor (OMF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 437
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccH
  • BacMet ID: BAC0555
  • Code for: Regulator
  • Family: Sigma-70 factor family. ECF subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 186
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccN
  • BacMet ID: BAC0554
  • Code for: Membrane Transporter
  • Family: Contains 1 Phospholipid methyltransferase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport.
  • Length (amino acid): 213
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccX
  • BacMet ID: BAC0553
  • Code for: Regulator
  • Family: contains 1 heavy-metal resistance domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 148
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccY
  • BacMet ID: BAC0552
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 95
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0263
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant determinant ncrA found both in chromosome and plasmids. Part of ncrABCY nickel resistance Chromosomal determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrC.
  • Length (amino acid): 432
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0698
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Part of the ncrABC determinant sytem. NcrA contributes to nickel and cobalt resistance in this bacterium.
  • Length (amino acid): 432
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0702
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrA protein. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 277
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0264
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant determinant ncrB which is cytoplasmic, histidine-rich protein found in both chromosome and plasmids; probabale metal-sensitive repressor, involved in resistance to nickel ions
  • Length (amino acid): 89
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0699
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 89
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0703
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrB protein. Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 301
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0265
  • Code for: Efflux
  • Family: NicOT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant membrane protein NcrC found both in chromosome and plasmids. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 376
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0700
  • Code for: Efflux
  • Family: Nickel-cobalt transport (NicOT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 231
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0704
  • Code for: Efflux
  • Family: Nickel-cobalt transport (NicOT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrC protein. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 152
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrY
  • BacMet ID: BAC0266
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosoaml nickel-resistant determinant ncrY found both in chromosome and plasmids; some claims it has a negative effect on nickel resistance.
  • Length (amino acid): 140
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrY
  • BacMet ID: BAC0701
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne NcrY protein. Part of ncrABCY nickel resistance determinant system. Some claims it has a negative effect on nickel resistance.
  • Length (amino acid): 63
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    nczA
  • BacMet ID: BAC0267
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Caulobacter crescentus (strain NA1000 / CB15N)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co), Zinc (Zn)
  • Description: Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+
  • Length (amino acid): 1057
  • Reference: Valencia et al. 2013; Pubmed- 23578014

    		• Similar resistance genes in 'BacMet Predicted database'
    nia
  • BacMet ID: BAC0269
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium melitoli
  • Location: Plasmid pSymA (Sinorhizobium melitoli)
  • Compound: Iron (Fe), Nickel (Ni)
  • Description: P1B-5-ATPase; Has role in detoxification of Fe (II)+ and Ni (II)+ under free living conditions as well as in symbiosis.
  • Length (amino acid): 799
  • Reference: Zielazinski et al. 2013; Pubmed- 24056637

    		• Similar resistance genes in 'BacMet Predicted database'
    nikA
  • BacMet ID: BAC0270
  • Code for: Binding protein
  • Family: Bacterial solute-binding protein 5 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel-binding periplasmic protein nikA; Involved in a nickel transport system, represents the nickel binder. Part of the Nik operon (NikABCDE), Solute-binding protein
  • Length (amino acid): 524
  • Reference: Wu et al. 1991; Pubmed- 1743519, De Pina et al. 1995; Pubmed- 7867647

    		• Similar resistance genes in 'BacMet Predicted database'
    nikB
  • BacMet ID: BAC0271
  • Code for: Membrane Transporter
  • Family: Binding-protein-dependent transport system permease family. OppBC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel transport system permease protein NikB; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 314
  • Reference: Wu et al. 1991; Pubmed- 1743519, Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikC
  • BacMet ID: BAC0272
  • Code for: Membrane Transporter
  • Family: Binding-protein-dependent transport system permease family. OppBC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel transport system permease protein NikC; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 277
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikD
  • BacMet ID: BAC0273
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Nickel importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel import ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 254
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikE
  • BacMet ID: BAC0274
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Nickel importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel import ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 268
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikR
  • BacMet ID: BAC0275
  • Code for: Regulator
  • Family: Transcriptional regulatory CopG/NikR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel-responsive regulator nikR; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
  • Length (amino acid): 133
  • Reference: De Pina et al. 1999; Pubmed- 9882686, Contreras et al. 2003; Pubmed- 12890020

    		• Similar resistance genes in 'BacMet Predicted database'
    nirA
  • BacMet ID: BAC0276
  • Code for: Membrane Transporter
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirA. C-terminal of the nirA protien contains a histidine rich region tat might possess high affinity to nickel.
  • Length (amino acid): 356
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirB
  • BacMet ID: BAC0277
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirB. It has 98% amino acid sequence similarity to chromosomal ncrB.
  • Length (amino acid): 89
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirC
  • BacMet ID: BAC0278
  • Code for: Membrane Transporter
  • Family: NicO transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirC. It is a memebrane protein like ABC-type transport proteins and also possess a histidine rich region with high affinity for nickel binding.
  • Length (amino acid): 307
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirD
  • BacMet ID: BAC0279
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirD; has 75% amino acid sequence similarity to chromomosomal ncrY.
  • Length (amino acid): 164
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nixA
  • BacMet ID: BAC0280
  • Code for: Enzyme
  • Family: NiCo transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Plasmid pRHL2 (Rhodococcus sp. (strain RHA1))
  • Compound: Nickel (Ni)
  • Description: High-affinity nickel intake protein nixA. Imports nickel ions in an energy-dependent fashion. Necessary for the Expression of catalytically active urease.
  • Length (amino acid): 331
  • Reference: Mobley et al. 1995; Pubmed- 7651142

    		• Similar resistance genes in 'BacMet Predicted database'
    nmtR
  • BacMet ID: BAC0281
  • Code for: Regulator
  • Family: ArsR-SmtB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cadmium (Cd), Lead (Pb)
  • Description: Represses transcription of ctpJ/nmtA, by binding to its promoter region
  • Length (amino acid): 120
  • Reference: Cavet et al. 2002; Pubmed- 12163508

    		• Similar resistance genes in 'BacMet Predicted database'
    nreB
  • BacMet ID: BAC0285
  • Code for: Enzyme
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acromobacter xylosoxidans 31A, Synechocystis spp.
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel resistance protein nreB (also known as nrsD or entS); nickel permease involved in nickel and cobalt tolerance. The histidine-rich C-terminal region of the nreB is not essential but contributes to maximal Ni(II) resistance.
  • Length (amino acid): 416
  • Reference: Grass et al. 2001; Pubmed- 11292799

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsA
  • BacMet ID: BAC0286
  • Code for: Membrane Transporter
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Cation or drug efflux system protein nrsA
  • Length (amino acid): 1054
  • Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsD/nreB
  • BacMet ID: BAC0287
  • Code for: Enzyme
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter calcoaceticus (strain PHEA-2), Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: nrsD gene encodes a Ni(II) permease whose carboxy-terminal region is a metal binding domain; nickel permease involved in nickel and cobalt tolerance
  • Length (amino acid): 445
  • Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsR
  • BacMet ID: BAC0288
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / GT-S)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: OmpR subfamily protein NrsR/RppA/Rre33
  • Length (amino acid): 234
  • Reference: Lopez-Maury et al. 2002; Pubmed- 11849552

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsS
  • BacMet ID: BAC0289
  • Code for: Enzyme
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / GT-S)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Sensory transduction histidine kinase NrsS/RppB/Hik30
  • Length (amino acid): 454
  • Reference: Lopez-Maury et al. 2002; Pubmed- 11849552

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnA/yohM
  • BacMet ID: BAC0330
  • Code for: Efflux
  • Family: NicO transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni), Iron (Fe)
  • Description: Efflux system rcnA for nickel and cobalt; Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcription
  • Length (amino acid): 274
  • Reference: Rodrigue et al. 2005; Pubmed- 15805538, Koch et al. 2007; Pubmed- 17120142

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnB/yohN
  • BacMet ID: BAC0331
  • Code for: Efflux
  • Family: RcnB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Nickel/cobalt homeostasis protein RcnB; Act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. Repressed by RcnR. Induced by nickel and cobalt
  • Length (amino acid): 112
  • Reference: Bleriot et al. 2011; Pubmed- 21665978

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnR/yohL
  • BacMet ID: BAC0332
  • Code for: Regulator
  • Family: FrmR/RcnR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni), Iron (Fe)
  • Description: Repressor of rcnA, rcnR. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Can repress the rcnB expression as well.
  • Length (amino acid): 90
  • Reference: Koch et al. 2007; Pubmed- 17120142

    		• Similar resistance genes in 'BacMet Predicted database'
    yqjH
  • BacMet ID: BAC0452
  • Code for: Enzyme
  • Family: SIP oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Nickel (Ni)
  • Description: NADPH-dependent ferric-chelate reductase (Ferric siderophore reductase) YqjH; Plays a role in iron homeostasis under excess nickel conditions; Repressed by YqjI and Fur. YqjI is required for nickel-dependent regulation of yqjH, while Fur is required for iron- and cobalt-dependent regulation of yqjh
  • Length (amino acid): 254
  • Reference: Wang et al. 2011; Pubmed- 21097627

    		• Similar resistance genes in 'BacMet Predicted database'
    zupT/ygiE
  • BacMet ID: BAC0469
  • Code for: Porter
  • Family: ZIP transporter family, ZupT subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)
  • Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.
  • Length (amino acid): 257
  • Reference: Grass et al. 2005; Pubmed- 15716430

    		• Similar resistance genes in 'BacMet Predicted database'
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